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Pompeo landed her first major role in 2005 on the ABC medical drama series Grey's Anatomy, created by Shonda Rhimes.She plays the title character and series' protagonist, Meredith Grey, a surgical intern at a prestigious hospital.

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A turning point came in her career in 2002, when she gained wide recognition for her starring role in Brad Silberling's drama Moonlight Mile.

Pompeo was then cast in ABC's popular medical drama Grey's Anatomy (2005–present), and garnered worldwide recognition for her portrayal of the title character Dr. The role on the long running series earned her a Golden Globe nomination and the Screen Actors Guild Award.

She portrayed Jim Carrey's ex-girlfriend, Naomi, in the 2004 film Eternal Sunshine of the Spotless Mind.

Although her scenes were cut from that film, she felt grateful that director Michel Gondry selected her for his film.

Ellen Kathleen Pompeo (born November 10, 1969) is an American actress, director and producer.